HyBioComBone
Novel hybrid biomimetic macroporous composites with tuned biodegradability, improved osteointegration and anticancer properties for bone tissue regeneration
years
of research and development
team members
institutions
with a distinguished history
posibilities
for improvement & upgrade
Problem we are motivated to solve
The treatment of large bone defects (LBDs) caused by trauma, infections, or tissue resections due to cancer, requires multiple surgeries with long recovery times leading to deteriorated life quality and increased healthcare costs. Synthetic implants used in clinical practice have many drawbacks, such as infection during or after implantation, poor integration, slow remodelling, and mechanical loosening, etc. In the case of malign bone tumors, chemotherapy is also necessary after the surgery. The ideal bone substitute should be biocompatible, osteoconductive, controlled resorbable, and thereby replaced by newly formed bone while maintaining adequate mechanical strength and structural support in the meantime. Additionally, it is beneficial for implants to possess antimicrobial and/or antitumor properties.
Project aim
Development of biocompatible, osteoconductive, macroporous composites with tuned biodegradability for bone repair and regeneration, based on hydrogels and multi-doped particles of calcium-phosphates and bioglass, in the form of scaffolds, microgels and 3D printed macroporous forms. In the biocomposites with optimal properties will be incorporated: a) antimicrobial and anticancer drugs for the prevention of infection and cancer, b) extracellular vesicles for improved osteointegration and bone tissue regeneration.
Project methodology
The composites will be designed by combining the interpenetrating network hydrogels based on synthetic and natural polymers and inorganic particles of nanostructured bioglass, and calcium phosphates multi-doped with various ions.
Composites with optimal mechanical properties and biodegradability will be further developed in three directions:
derived from adipose-derived stem cells (ADSCs) for providing improved osteointegration and bone tissue regeneration.
(commercial and newly synthesized drugs providing novel cancer treatment).
controlled delivery of antibiotics for infection prevention.
Project grant: No. 7740
Project financed by: Science Fund of the Republic of Serbia – PRIZMA programme
Period of realization: January 2024 – January 2027.
Team
Our team gathers 14 experts from 5 institutions.
Faculty of Technology and Metallurgy, University of Belgrade
Innovation Centre of the Faculty of Technology and Metallurgy Ltd.
School of Dental Medicine, University of Belgrade
The Faculty of Medical Sciences, University of Kragujevac
“Vinča” Institute of Nuclear Sciences, University of Belgrade
Djordje Veljovic, PhD • TMF
Associate Professor
– Principal Investigator –
Rada Petrovic, PhD • TMF
Full Professor
– Coordinator of WP –
Djordje Janackovic, PhD • TMF
Full Professor
– Coordinator of WP –
Biljana Ljujic, PhD • FMSUKG
Full Professor
– Coordinator of WP –
Milena Radunovic, PhD • STOMF
Assistant Professor
– Biomedical evaluation –
Zeljko Radovanovic, PhD • ICTMF
Senior Research Associate
– Development of new materials-
Vukasin Ugrinovic, PhD •
ICTMF
Research Assistant
– Development of new materials-
Ivica Vujcic, PhD • VINS
Research Associate
– Development of new materials-
Milos Papic, PhD • FMSUKG
Assistant Professor
– Biomedical evaluation –
Tamara Matić • TMF
Teaching Assistant
– Development of new materials-
Marija Milivojevic • ICTMF
Research Assistant
– Biomedical evaluation –
Tamara Vlajic Tovilovic • STOMF
Junior Research Assistant
– Biomedical evaluation –
Irena Ognjanovic •
FMSUKG
Junior Research Assistant
– Biomedical evaluation –
Publications
- G. Ayoub, Dj. Veljović, M. Ležaja Zebić, V. Miletić, E. Palcevskis, R. Petrović, Dj. Janaćković, “Composite nanostructured hydroxyapatite/yttrium
stabilized zirconia dental inserts – The processing and application as dentin substitutes“, Ceramics International, 44 (2018) 18200-18208
(doi.org/10.1016/j.ceramint.2018.07.028).
- Dj. Veljović, T. Matić, T. Stamenić, V. Kojić, S. Dimitrijević-Branković, M. J. Lukić, S. Jevtić, Ž. Radovanović, R. Petrović, Dj. Janaćković,
“Mg/Cu co-substituted hydroxyapatite – biocompatibility, mechanical properties and antimicrobial activity“, Ceramics International, 45 (2019)
22029-22039 (doi.org/10.1016/j.ceramint.2019.07.219).
- A. Kazuz, Ž. Radovanović, Dj. Veljović, V. Kojić, V. Miletić, R. Petrović, Dj. Janaćković, “α-Tricalcium phosphate/fluorapatite based composite
cements: Synthesis, mechanical properties, and biocompatibility”, Ceramics International, 46 (2020) 25149-25154
(doi.org/10.1016/j.ceramint.2020.06.301).
News
HyBioComBone project commenced
On January 1, 2024, the HyBioComBone project officially commenced, marking a revolutionary step towards addressing challenges in treating large bone […]
Kick-off meeting
A kick-off meeting of the team members took place at the Faculty of Technology and Metallurgy, University of Belgrade. At […]
LinkedIn and Instagram profiles
Now you can follow us through our social media accounts on LinkedIn and Instagram profiles! Connect with us to stay […]
Synthesis of Multi-Doped Mesoporous Bioactive Glass
Our Bioceramic team members are currently focused on development of multi-doped bioactive mesoporous glass particles with optimal composition for simultaneous […]
ExcellMater Conference
At the ExcellMater2024 conference, our team shared experiences and knowledge with leading scientists in the field of biomaterials, including prof. […]
66th International Fair of Technics
HyBioComBone at the 66th International Fair of Technics and Technical Achievements at the exhibition of innovations and new technologies! Visit […]
New publication – Vukašin Ugrinović
V. Ugrinović, M. Marković, B. Božić, V. Panić, Dj. Veljović, “Physically Crosslinked Poly(methacrylic acid)/Gelatin Hydrogels with Excellent Fatigue Resistance and […]
New publication – Tamara Matić
Matić T., Daou F., Cochis A., Barac N., Ugrinovic V., Rimondini L., Veljovic Đ.: Multifunctional Sr,Mg-doped mesoporous bioactive glass nanoparticles for […]
Yucomat 2024
HyBioComBone presenting results at the Yucomat Conference 2024 in Herceg Novi, Montenegro. https://www.mrs-serbia.org.rs/index.php/book-of-abstracts-2024
Elmina 2024
Elmina 2024 conference just started where HyBioComBone team presented results on the multi-ion-doped mesoporous bioactive glass.
2nd MOVE Symposium – Belgrade 2024
Excited to share that our team members participated in the 2nd MOVE Symposium last week in Belgrade! It’s a fantastic opportunity […]
Banjaluka 2024
Our team members presented a scientific research “Advancements in novel bioactive nanomaterials for biomedical and dental uses” at the Conference […]
Training PhD students
Empowering the next generation of researchers! Marija, a member of the HyBioComBone team, provided hands-on training on sterile techniques to […]
22nd Young Researchers Conference
Team member Marija Milivojevic, PhD student Teodora Jakovljevic and our PI prof Djordje Veljovic attended the 22nd Young Researchers Conference […]
Contact us
Principal Investigator prof. dr Djordje Veljovic
Faculty of Technology and Metallurgy, University of Belgrade 
djveljovic@tmf.bg.ac.rs
Karnegijeva 4, 11000 Belgrade
